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10.1073/pnas.1516953113 Proc

suggests that TB-500 may shape cell movement as it binds globular actin (G-actin) and may adjust how actin filaments assemble to plausibly render cells more capable of changing shape, migrating, and organizing into multicellular structures

It binds to and activates human GHRH receptors with a potency akin to endogenous GHRH

By regulating the balance of Bcl-2 family proteins, metformin promotes apoptosis through the mitochondrial pathway (66)